By Katok Sinai

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A solution of Eq. t / and R2 D ˛mmax where mmax is the absolute maximum level to which the malignant mass could get around a blood vessel. t /. t / (14) An empirical validation of the analytical conclusions is carried out with the use of the leukemia data of Skipper and Perry [14]. Their work with the data revealed that the best fitting curve is the Gompertz curve in comparison with fits of the logistic, exponential, and cubic curves. Expression (13) basically suggests that malignant growth of disseminated cancer cells can be sandwiched between two Gompertzians.

X/ satisfies k X j D0 . 1/ j ! e. x 2 E. It might be fruitful to try to transplant all of the results previously mentioned to this higher dimensional context. Acknowledgements The author’s research was partially supported by a Summer Research Grant, College of Science and Health, DePaul University. This paper is dedicated to Calixto Calderón. : Generalizations of the Riemann derivative. Trans. Am. Math. Soc. : Quantum symmetric Lp derivatives. Trans. Am. Math. Soc. : Generalized vs. ordinary differentiation.

A version of Taylor’s theorem that is slightly stronger than the usual ones found in calculus texts was proved by de la Vallée-Poussin in the late nineteenth century. x/. The first derivative and the first Peano derivative have the same definition. x/ h : The other generalized derivative involving polynomial approximation is the symmetric (Peano) derivative. hn / as h ! hn / as h ! x/. n/ The second level of generalization consists of higher order derivatives that are defined directly as difference quotients.